Luteinising Hormone (LH)
- C1131
Rs 500
- Why Get Tested?
Luteinizing Hormone, serum or urine - When To Get Tested?
To evaluate fertility issues, function of reproductive organs (ovaries or testicles), or to detect the release of an egg from the ovary (ovulation); to evaluate pituitary function In children, to evaluate early or delayed sexual maturation (puberty) - Sample Type:SERUM (SST or Plain)
- Fasting :YES (10 to 12 Hours)
- Report Delivery:within 48 Hrs of Test Schdule
- Components:1 Observations
Tests Detail
| Observations Included |
| Luteinising Hormone (LH) * |
| The Test marked with (*) are in our NABL Scope. |
Sample Report
- Also Known As:
Luteinizing Hormone (LH) - Formal Name:
Luteinizing Hormone Lutropin Interstitial Cell Stimulating Hormone ICSH - Sample Instructions:
For women, when you are having difficulty getting pregnant or are having irregular or heavy menstrual periods; when you are tracking ovulation during your menstrual cycle For men, when your partner cannot get pregnant or you have a low sperm count, low muscle mass or decreased sex drive When your healthcare provider thinks that you have symptoms of a pituitary disorder or hypothalamic disorder When a health practitioner suspects that a child has delayed or earlier than expected sexual maturation - Test Preparation Needed?
A blood sample drawn from a vein in your arm; sometimes a random urine sample or a 24-hour urine collection may be taken - What Is Being Tested?
None, but the timing of a woman's sample will be correlated with her menstrual cycle. - How Is It Used?
Luteinizing hormone (LH) is a hormone associated with reproduction and the stimulation of the release of an egg from the ovary (ovulation) in women and testosterone production in men. This test measures the amount of luteinizing hormone in the blood or urine. LH is produced by the pituitary gland, a grape-sized organ found at the base of the brain. Control of LH production is a complex system involving the hypothalamus in the brain, the pituitary gland, and the hormones produced by the ovaries and testicles. In premenopausal women, several hormones rise and fall in a specific sequence during each menstrual cycle. During the cycle, LH stimulates ovulation and the production of other hormones, estradiol and progesterone. Womens' menstrual cycles are divided into follicular and luteal phases, with each phase lasting about 14 days. Near the end of the follicular phase, there is a mid-cycle surge of follicle-stimulating hormone (FSH) and LH. This surge triggers ovulation, causing the rupture of the egg follicle on the ovary and the release of the egg. During the luteal phase, the site where the egg follicle ruptured becomes a "corpus luteum." LH secretion stimulates the corpus luteum to start producing progesterone. FSH and LH levels decline, while progesterone and estradiol concentrations increase. These hormone levels decrease in turn after several days if the egg is not fertilized. Menstruation starts and when it ends, the cycle begins again. As a woman ages and menopause approaches, ovarian function wanes and eventually ceases. As this occurs, FSH and LH levels rise. In men, LH stimulates Leydig cells in the testicles to produce testosterone. LH levels are relatively constant in men after puberty. A high testosterone level provides negative feedback to the pituitary gland and the hypothalamus, thus decreasing the amount of LH secreted. In infants and children, LH levels rise shortly after birth and then fall to very low levels (by 6 months in boys and 1-2 year - When Is It Ordered
The test for luteinizing hormone (LH), a hormone associated with reproduction and the stimulation of the release of an egg from the ovary (ovulation) in women and testosterone production in men, has several uses. In both women and men, LH is often used in conjunction with other tests (FSH, testosterone, estradiol and progesterone): In the workup of infertility To aid in the diagnosis of pituitary disorders that can affect LH production To help diagnose conditions associated with dysfunction of the ovaries or testicles In women, LH levels are useful: In the investigation of menstrual irregularities To evaluate LH levels during the menstrual cycle; multiple urine LH tests may be ordered for this purpose. These LH "spot tests" can be performed at home and used to detect the surge in LH that indicates that ovulation will occur in the next 1-2 days. The tests can help determine when a woman is likely to be the most fertile. In children, FSH and LH are used to diagnose delayed and precocious (early) puberty. Irregular timing of puberty may be an indication of a more serious problem involving the hypothalamus, the pituitary gland, the ovaries or testicles, or other systems. The measurement of LH and FSH may differentiate between benign symptoms and true disease. Once it is established that symptoms are a result of true disease, further testing can be done to discern the underlying cause. In persons with evidence of poor ovarian or testicular function, LH is sometimes measured in response to administration of gonadotropin releasing hormone (GnRH) to distinguish between disorders involving the hypothalamus or pituitary gland. GnRH is the hormone produced by the hypothalamus that stimulates the pituitary to release LH and FSH. For this test, a baseline blood sample is drawn and then the person is given an injection of GnRH. Subsequent blood samples are drawn at specified times and the level of LH is measured. This test can help differentiate between - What Does The Test Result Mean?
In adults, LH (and FSH) tests may be ordered when: A woman is having difficulty getting pregnant or has irregular or an absence of menstrual periods When it is suspected that a women has entered menopause and her menstrual cycle has stopped or become irregular When a man's partner cannot get pregnant, when he has a low testosterone level, or when he has low muscle mass or decreased sex drive, for example. When a health practitioner suspects that a pituitary disorder is present; a pituitary disorder can affect the production of several different hormones so there may be signs and symptoms in addition to infertility that can include fatigue, weakness, unexplained weight loss, and decreased appetite to name a few. In children, LH and FSH may be ordered when a boy or girl does not appear to be entering puberty at an appropriate age (either too late or too soon). Signs of puberty may include: Breast enlargement in girls Growth of pubic hair Growth of testicles and penis in boys Beginning of menstruation in girls - Is There Anything Else I Should Known?
In Women LH and FSH levels can help to differentiate between primary ovarian failure (failure of the ovaries themselves or lack of ovarian development) and secondary ovarian failure (failure of the ovaries due to disorders of either the pituitary or the hypothalamus). Increased levels of LH and FSH are seen in primary ovarian failure. Some causes of primary ovarian failure are listed below. Developmental defects: Failure to develop ovaries (ovarian agenesis) Chromosomal abnormality, such as Turner syndrome Defect in steroid production by the ovaries, such as 17 alpha hydroxylase deficiency Premature ovarian failure due to: Exposure to radiation Chemotherapy Autoimmune disease Chronic failure to ovulate (anovulation) due to: Polycystic ovary syndrome (PCOS) Adrenal disease Thyroid disease Ovarian tumor In women who are trying to become pregnant, multiple LH tests can be used to detect the surge that precedes ovulation. An LH surge indicates that ovulation has occurred. During menopause, a woman's ovaries cease to function; thus LH levels will rise. Low levels of LH and FSH are seen in secondary ovarian failure and indicate a problem with the pituitary or hypothalamus. See the article on Pituitary Disorders for more information. In Men High LH levels may indicate primary testicular failure. This can be due to developmental defects in testicular growth or to testicular injury, as described below. Developmental defects: Failure to develop gonads (gonadal agenesis) Chromosomal abnormality, such as Klinefelter syndrome Testicular failure: Viral infection (mumps) Trauma Exposure to radiation Chemotherapy Autoimmune disease Germ cell tumor Low levels of LH and FSH are seen in secondary failure of the testicles and indicate a problem with the pituitary or hypothalamus. See the article on Pituitary Disorders for more information. In Both Men and Women LH response to GnRH can help diffe
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